Tuesday, October 1, 2024
Video Part 1: Introduction & Spotlight on Nancy (Natl Dense Breast Disclosure Act)
Monday, September 23, 2024
RECURRENCE EXPLAINED- POSTOP SCANNING
RECURRENCE IN REVIEW
Transcript by Dr. Roberta Kline
There is a constant debate in the cancer community about the term "CANCER FREE". Cancer recurrence continues to be a major concern as reported in annual medical reports- identifying its tendency to “return with a vengeance". [1, 2]
Medical research has identified the major reasons why cancer recurs. A widely reported cause for this is attributed to a deficiency in treatment performance. [2] This means the therapy induced did not successfully remove or kill all of the cancer cells, possibly due to the patient's level of drug resistance. During treatment, Cancer cells can enter a dormant state to protect themselves from treatment and other stimuli. Over time, these dormant cells can reactivate. The cause of this may be a spike in chronic stress or the release of toxins from oxidative stress from environmental factors like smoking or repeat exposure to reactive chemicals. [3]Inflammation has also been linked to the activation of immune cells called neutrophils. [4] Cancer cells that have spread to other areas of the body after successful treatment of the original tumor can remain dormant for years or decades before recurring as metastatic cancer. Further activators of these dormant cells have also been linked to one's personal Epigenetics. [5] This determines how your environment and lifestyle affects your cell function- including the dormancy state of your cancer cells.
Another known cause for recurrence are Cancer stem cells or CSC's. These are a small group of cells in tumors that have the ability to self-renew, differentiate, and give rise to all cell types in a tumor. [6] Most stages of tumor progression, including tumorigenesis, promotion, progression, and recurrence are accompanied by epigenetic alterations, some of which can be reversed by epigenetic drugs. [6]
DETECTION MONITORING: After cancer surgery, there are many preventive measures to support a safe and healthy recovery and to reduce the risk of recurrence. A logical and preventive strategy as part of postop maintenance is called RECURRENCE PREVENTION SCANS. Through the use of affordable, real-time medical imaging such as the 3D Doppler Ultrasound, post-cancer surgery patients can subscribe to a personal monitoring regimen to scan for any potential lesions and micro-tumors that may have fallen under the radar. Proactive monitoring can also address complications such as post-surgical Infections, recurring pain, swelling, neuropathy from nerve damage, scarring, fluid buildup or blood clots. In less than 20 minutes per visit, you earn peace of mind from a comprehensive scan by seasoned specialists trained to support postop patient management.
(1.) Butow P, Sharpe L, Thewes B, et al. Fear of Cancer Recurrence: A Practical Guide for Clinicians. Oncology (Williston Park). 2018 Jan 15;32(1):32-8. (2.) Mahvi DA, Liu R, Grinstaff MW, et al. (2018). Local Cancer Recurrence: The Realities, Challenges, and Opportunities for New Therapies. CA: A Cancer Journal for Clinicians, 68(6), 488. https://doi.org/10.3322/caac.21498 (3.) Payne KK. Cellular stress responses and metabolic reprogramming in cancer progression and dormancy. Seminars in cancer biology 2022 Jan Vol. 78, pp. 45-48. (4.) He X-Y, Gao Y, Ng D et al. Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment. Cancer Cell 2024:42(3);474-486. DOI: https://doi.org/10.1016/j.ccell.2024.01.013 (5.) Costa S, Alves Sales SL, Pinheiro DP, et al. (2023). Epigenetic reprogramming in cancer: From diagnosis to treatment. Frontiers in Cell and Developmental Biology, 11. https://doi.org/10.3389/fcell.2023.1116805 (6.) Yu X, Zhao H, Wang R, et al. (2024). Cancer epigenetics: From laboratory studies and clinical trials to precision medicine. Cell Death Discovery, 10(1), 1-12. https://doi.org/10.1038/s41420-024-01803-z
WHAT'S NEXT AFTER CANCER?
The
Importance of Maintaining a Healthy Lifestyle and Monitoring
Written by: Dr. Leslie Valle-Montoya
CONTRIBUTOR:
Announcing the TSCCC (TriState Cancer Care Community)- a professional network comprised of community leaders, legislators, health specialists & educators. We are backed by the AngioInstitute (501c3) and are aligned by cancer foundations centralized in the NY, NJ and CT. We assemble the latest information, current news events, research reports, technologies and success stories about the battle against cancer and the luminaries who wage them. |
9/10/2024- A NEW TOUCHDOWN IN THE FIGHT AGAINST BREAST CANCER- DENSE BREAST DISCLOSURE LAW CONFIRMED
9/10/2024- The Dense Breast Disclosure Law was officially confirmed at the Legislative Building in the CT State Capitol, hosted by the ‘Are You Dense Advocacy’ organization. The conference was emceed by Mr. Joe Cappello, co-founder and executive director, establishing both a celebration and an historical landmark for the 20+ year crusade for a national legislation. The law affirms the vision of the late Dr. Nancy Cappello for a public educational advocacy to protect women from misinformation about their breast health. This initiative enacted national support for legislative action to enforce patient disclosure about tissue density. (See full report)
AT LAST! "ARE YOU DENSE ADVOCACY" LANDS 20-YEAR TOUCHDOWN:Congresswoman DeLauro Celebrates National Support for Women’s Health
Click to see Sen DeLauro's Video |
A powerful voice in national Women's Health advocacy resonated from the back of the room, where a familiar face from the big-screen took center stage. The highly-beloved CT Congresswoman Rosa DeLauro transmitted a compelling video message from Washington and received a rousing applause with many tears of loving support. “Today we celebrate the launch of the Food and Drug Administration's Breast Density Notification Rule. I am a 35 year cancer survivor. I'm alive today thanks to the grace of God, the care of hardworking medical professionals, the power of biomedical research and early detection. In 2009, this law was championed by my dear friend Dr. Nancy Capello, who passed away several years ago due to breast cancer...Had Nancy been notified of her status earlier, she may have been here today to celebrate with us. Nancy's husband (Joe) carried on her fight and their story inspired me. I want to thank you again for inviting me to join you today. I urge you to keep up the fight.”
Thanks to the power of web-streaming technology, an unconfirmed count of breast cancer orgs nationwide (and their respective members) accessed the live feed of the Are You Dense? event. Donna Johnson, president of ‘Are You Dense?’ mentioned about an upcoming virtual (seminar-style) event which will launch sometime in mid-October- bringing in some of the top names in public advocacy as well as leaders from the medical community.
For more info. on this press release, contact ‘Are You Dense Alliance’ (multimedia dist.) / Alexandra Fiederlein: editor.prevention101@gmail.com or call 516-522-0777
Click to see Den. Anwar's Videos |
SEN. SAUD ANWAR
CONNECTICUT STATE SENATE ADVOCATES FOR UNDERSERVED WOMEN
7/13/2024 ‐ The Women's Health Collaborative proudly celebrates the dedicated commitment and support of STATE SENATOR SAUD ANWAR (D‐South Windsor) of District 3 for his legislative work in health initiatives for women. A pulmonary physician by profession, Sen. Anwar joined public office in 2013 as mayor of South Windsor, CT (until 2015, and 2017‐2019). Senator Anwar is involved in humanitarian and peace initiatives nationally and internationally. He is frequently invited to consult for our government and has organized medical missions for disaster relief. His efforts have been recognized at the state and federal levels and by several professional organizations. He has received numerous citations for his service to the State and is an expert on international affairs.[1]
WOMEN’S HEALTH COLLABORATIVE GOES TO ALBANY
(Play Video-L) The NY Cancer Resource Alliance gives loving tribute to Dr. Nancy Cappello, co-founder of "Are You Dense" and chief crusader of the mission to bring change to the protocols and standards of Early Detection. Her organization embarked in a global advocacy project to win legislation for dense breast scanning and to bring awareness to the need for better technologies and imaging interpretation. Today, her loving husband Joe continues her unending fight to save more lives through awareness, advocacy and her crusade for change. |
ADVOCACY & JOINING HANDS TO MAKE A DIFFERENCE
By: Geri Barish - Hewlett House (Cancer Resource)
EXTRA: 2024 UPDATES ON DENSE BREAST RESEARCH
3/2024- Dr. Noelle Cutter of Molloy University and an associate of Bard Diagnostics/Are You Dense? partnerships conducted an observational study exploring the functional phenotypic differences that make dense breast tissue. Because it is widely noted that women with dense breasts have a greater likelihood of developing cancer, understanding the pathways and changes in gene expression may offer the first avenue for the enzymes enrolled and drug targets for personalized medicine in pursuit of developing better treatment options. “The proposed role of senescence in dense breast tissue metastasis involves creating a tumor-promoting microenvironment, facilitating immune evasion, and promoting angiogenesis, all of which contribute to the progression and spread of cancer cells.”- For full report, visit: www.pinksmartnews.com
The 2024 Women's Health Resource Network Launches Ultrasound Screening Initiative for Underserved Communities
Density under mammograms conceal tumors & cysts. Ultrasound is the suggested screening complement |
Saturday, September 14, 2024
9/10/2024- A NEW TOUCHDOWN IN THE FIGHT AGAINST BREAST CANCER- DENSE BREAST DISCLOSURE LAW CONFIRMED
AT LAST! "ARE YOU DENSE ADVOCACY" LANDS 20-YEAR TOUCHDOWN:
Legislation for National Support for Women’s Health
9/10/2024- The Dense Breast Disclosure Law was officially confirmed at the Legislative Building in the CT State Capitol, hosted by the ‘Are You Dense Advocacy’ organization. The conference was emceed by Mr. Joe Cappello, co-founder and executive director, establishing both a celebration and an historical landmark for the 20+ year crusade for a national legislation. The law affirms the vision of the late Dr. Nancy Cappello for a public educational advocacy to protect women from misinformation about their breast health. This initiative enacted national support for legislative action to enforce patient disclosure about tissue density.
Click to see Sen DeLauro's Video |
A powerful voice in national Women's Health advocacy resonated from the back of the room, where a familiar face from the big-screen took center stage. The highly-beloved CT Congresswoman Rosa DeLauro transmitted a compelling video message from Washington and received a rousing applause with many tears of loving support. “Today we celebrate the launch of the Food and Drug Administration's Breast Density Notification Rule. I am a 35 year cancer survivor. I'm alive today thanks to the grace of God, the care of hardworking medical professionals, the power of biomedical research and early detection. In 2009, this law was championed by my dear friend Dr. Nancy Capello, who passed away several years ago due to breast cancer...Had Nancy been notified of her status earlier, she may have been here today to celebrate with us. Nancy's husband (Joe) carried on her fight and their story inspired me. I want to thank you again for inviting me to join you today. I urge you to keep up the fight.”
Dr. Lennard Gettz from NY spoke on behalf of the Integrative Cancer Resource Society and the Women's Health Collaborative. He delivered a combined statement from top members including Dr. Robert Bard (NYC), Dr. Noelle Cutter (NY), Dr. Roberta Kline (NM), Dr. Nancy Novack (AZ), Dr. Leslie Valle-Montoya (CA) and Geri Barish (Hewlett House/NY). "The battle against breast cancer is waged from many fronts; we all need to do our part to improve on the clinical diagnostics and therapeutic modalities while bringing renewed empowerment to all sufferers inflicted by cancer. We are also here together to enforce awareness to the underserved and the underdiagnosed women who needs hope. To address all these needs simultaneously is where the battle rages on- and that's where you will find us standing together... with ‘Are You Dense?’ and the many other champions whose courage pushes for a global upgrade in saving lives!"Thanks to the power of web-streaming technology, an unconfirmed count of breast cancer orgs nationwide (and their respective members) accessed the live feed of the Are You Dense? event. Donna Johnson, president of ‘Are You Dense?’ mentioned about an upcoming virtual (seminar-style) event which will launch sometime in mid-October- bringing in some of the top names in public advocacy as well as leaders from the medical community.
For more info. on this press release, contact ‘Are You Dense Alliance’ (multimedia dist.) / Alexandra Fiederlein: editor.prevention101@gmail.com or call 516-522-0777
* Special thanks to THE CONNECTICUT NETWORK for sharing the complete video coverage on the Dense Breast Disclosure Act conference.
Click to see Den. Anwar's Videos |
SEN. SAUD ANWAR
CONNECTICUT STATE SENATE ADVOCATES FOR UNDERSERVED WOMEN
7/13/2024 ‐ The Women's Health Collaborative proudly celebrates the dedicated commitment and support of STATE SENATOR SAUD ANWAR (D‐South Windsor) of District 3 for his legislative work in health initiatives for women. A pulmonary physician by profession, Sen. Anwar joined public office in 2013 as mayor of South Windsor, CT (until 2015, and 2017‐2019). Senator Anwar is involved in humanitarian and peace initiatives nationally and internationally. He is frequently invited to consult for our government and has organized medical missions for disaster relief. His efforts have been recognized at the state and federal levels and by several professional organizations. He has received numerous citations for his service to the State and is an expert on international affairs.[1]
WOMEN’S HEALTH COLLABORATIVE GOES TO ALBANY
(Play Video-L) The NY Cancer Resource Alliance gives loving tribute to Dr. Nancy Cappello, co-founder of "Are You Dense" and chief crusader of the mission to bring change to the protocols and standards of Early Detection. Her organization embarked in a global advocacy project to win legislation for dense breast scanning and to bring awareness to the need for better technologies and imaging interpretation. Today, her loving husband Joe continues her unending fight to save more lives through awareness, advocacy and her crusade for change. |
ADVOCACY & JOINING HANDS TO MAKE A DIFFERENCE
By: Geri Barish - Hewlett House (Cancer Resource)
EXTRA: 2024 UPDATES ON DENSE BREAST RESEARCH
3/2024- Dr. Noelle Cutter of Molloy University and an associate of Bard Diagnostics/Are You Dense? partnerships conducted an observational study exploring the functional phenotypic differences that make dense breast tissue. Because it is widely noted that women with dense breasts have a greater likelihood of developing cancer, understanding the pathways and changes in gene expression may offer the first avenue for the enzymes enrolled and drug targets for personalized medicine in pursuit of developing better treatment options. “The proposed role of senescence in dense breast tissue metastasis involves creating a tumor-promoting microenvironment, facilitating immune evasion, and promoting angiogenesis, all of which contribute to the progression and spread of cancer cells.”- For full report, visit: www.pinksmartnews.com
The 2024 Women's Health Resource Network Launches Ultrasound Screening Initiative for Underserved Communities
Density under mammograms conceal tumors & cysts. Ultrasound is the suggested screening complement |
Saturday, August 31, 2024
ADVANCING ON DENSE BREAST TISSUE : A 2024 REVIEW
A MESSAGE FROM WASHINGTON ON THE DENSE BREAST DISCLOSURE ACT: By Congresswoman Rosa DeLauro / Connecticut 3rd Congressional District
Today we celebrate the launch of the Food and Drug Administration's Breast Density Notification Rule. This is something that I have been working on for a long time. This issue is deeply personal for me. I am a 35 year cancer survivor. I'm alive today thanks to the grace of God, the care of hardworking medical professionals, the power of biomedical research and early detection.
As you know, Connecticut led the way in mandating all women receive information about breast density. In 2009, this law was championed by my dear friend Dr. Nancy Capello, who passed away several years ago due to breast cancer. 99% of women who receive an early breast cancer diagnosis survive it, but Nancy went through multiple mammograms and doctors did not detect tumors until Nancy was told she had dense breasts. Had Nancy been notified of her status earlier, she may have been here today to celebrate with us. Nancy's husband (Joe Cappello) carried on her fight and their story inspired me. I teamed up with Congressman Brian Fitzpatrick to introduce the Breast Density and Mammography Reporting Act requiring the Food and Drug Administration, which was ultimately signed into law in 2019. Now, the federal government is finally creating a national standard for notification.
We are celebrating that progress today while also using this moment to call attention to the fact that for most women, these screenings will still not be covered by insurance. The next step is to mandate all insurance coverage, to cover screenings and diagnostic mammograms, breast ultrasounds, and breast MRIs with no cost sharing nationwide.
I reintroduced the Find It Early Act with Representative Patrick earlier this year, which would require all health insurance plans to cover screening and diagnostic mammograms, breast ultrasounds, and MRIs with no cost sharing. I'm also grateful that award-winning journalist and cancer advocate, Katie Couric, has continued to be a champion of this critical legislation and had the courage to share her powerful story about early detection, which has been so helpful in amplifying our efforts and reaching people across the country.
The rule we are celebrating today is only one part of making screenings accessible. We must pass the Find It Early Act. Women's lives are at stake, and I will continue to fight like hell to get this bill passed. With that, I want to thank you again for inviting me to join you today. I urge you to keep up the fight.
PATHOLOGICAL VIEWS OF DENSE BREAST TISSUE
Written by: Dr. Robert L. Bard (12/2023)
Edited by: Carmen Regallo-Dewitt
Decades since the advent of breast scanning technology, innovations in non-invasive diagnostic imaging provide new options in the field of early detection. A mammogram can show how dense your breasts are including how low or high in density. However, over-compression artificially lowers the radiographic density.
[Image 1] in this standard mammogram, a dense breast is presented side by side. The white shaped “V” that comes down the top center are the pectoral muscles of the chest wall. On the far outside, the white line is the skin outline of the breast. This is the dermal tissue causing the white line viewed enface. Radiologists always study this for any indication of inflammatory disease of the skin or inflammatory breast cancer, which manifests itself in skin thickening. Between the center wedge and the skin outline, you will find homogeneous cloudy areas with patchy black spaces within as an example of dense breast tissue.
Usually, dense breast tissue appears white on a mammogram. We must identify them as one of two forms of breast density; one is called FIBROCYSTIC or fibrous [Image 2] which is homogeneously white. Occasionally you can see a branching of blood vessels, dilated ducts or a streak of fat inside the dense breast tissue. This is the most common type of dense breast tissue and generally seen in the over 40 population.[Image 3] Another example of a dense breast shows the difference between homogeneous white versus the whitish area. This is filled with dark, wormy looking structures, which are the breast glands called GLANDULAR tissue. This kind secretes milk and its glands are often dilated. Both Fibrous and Glandular may appear similar under a mammogram as highly dense areas, but they look completely different under an ultrasound scan.
Through ultrasound, we can check for tumors easily through fibrotic dense breasts because it stands out as a black region (or a black hole) within the white area. As shown in Image 3, a black hole could get lost, making it more difficult to image this type of dense breast. In this case, a solution is the use of elastography [Image 4], which offers visual confirmation as indicated by color data. Elastography can measure tissue density (its hardness or elasticity) within the glandular breast tissue.This tissue type is more common in the under-40 age group and is associated with other glandular proliferation such as endometriosis and is reportedly linked to dermal inflammation. In published reports, comparative studies between FIBROUS and GLANDULAR breast tissue studies remain limited. We are observing (especially in the younger age groups) expanding reviews of these types of tissue density aligned with the rates of breast cancer to confirm the rate of malignancy in tissue alteration from normal.
(Play Video-L) The NY Cancer Resource Alliance gives loving tribute to Dr. Nancy Cappello, co-founder of "Are You Dense" and chief crusader of the mission to bring change to the protocols and standards of Early Detection. Her organization embarked in a global advocacy project to win legislation for dense breast scanning and to bring awareness to the need for better technologies and imaging interpretation. Today, her loving husband Joe continues her unending fight to save more lives through awareness, advocacy and her crusade for change. (Also see below to read her full story in our ORG SPOTLIGHT section) |
Epigenetic Research Notes: Profiling the Dense Breast Paradigm (part 1)
Coursework (Part 1) written by: Dr. Roberta Kline.
As an Ob-Gyn physician and genomics specialist, I have spent the better part of 10 years translating research in the genomic and gene expression areas into clinically usable information for healthcare professionals. One of the biggest challenges we face when connecting research with patient care is the long delay in the translation process and dissemination of the information. It often takes 10 to 20 years for information (validated findings) that comes out of research to be applied in clinical practice. These delays result in many lost opportunities to provide better care for our patients. This is one of the reasons why I'm really passionate about accelerating this process and making it easier for clinicians and their patients to take advantage of cutting-edge information and new technologies.
We have known for a very long time that there is an increased risk of breast cancer for women who have dense breasts. Until recently, the research has been lagging in terms of what's the molecular mechanism, why do dense breasts present an increased risk of breast cancer? Without this knowledge, we can’t address the root causes, and are left with a lot of trial and error based on incomplete understanding. (see complete report)
LIVING WITH ENDOMETRIOSIS:
From an interview with MJ Smith
Advocacy for Endometriosis is directly related to my personal journey. Growing up with endometriosis since puberty, I've been to the emergency department probably over 20 times for pain or pelvic pain related conditions. The pain had me flat on my back for days at a time or falling out of bed with pain. I drove myself to a Planned Parenthood in Minnesota where I grew up and was prescribed birth control to manage it well into my twenties. Despite the hormonal treatments, I still had a series of episodes.
Endometriosis is the uterine tissue that grows and implants itself outside of the uterus. Going through that pain is the result of a complex process, resulting in swelling and bleeding inside the interstitial spaces of my body. Women who have endometriosis also often develop painful cysts on their ovaries.
I think the biggest reason you see women in the ER is pelvic pain. Women with chronic pelvic pain (which is often what endometriosis causes) are underserved by the healthcare community because we're constantly complaining of pelvic pain. The ER is not where you want treatment because you see a different doctor every time you get admitted. With emergency imaging, you usually get a pelvic ultrasound where cysts can show up and they're quick to assume that you have a cyst, or a cyst has burst and this is why you're uncomfortable. I think now you can do a pelvic MRI with contrast media- but it's still not enough to offer a definitive diagnosis. (See complete report)
- 1/19-2023- The ARE YOU DENSE ADVOCACY committee continued to pursue the public importance of patients receiving their own personal medical i...
- WHAT ABOUT IF YOU'RE TOO YOUNG FOR A MAMMOGRAM? I went to my doctor for a lump I felt in my breast and she gave me a response that se...
- FOR IMMEDIATE RELEASE NATIONAL CANCER ADVOCACY GROUP RECOGNIZES BARD DIAGNOSTIC RESEARCH FOR ADVANCEMENTS IN DENSE BREAST IMAG
Copyright © 2023- Robert L. Bard, MD & cancerscan.com. All rights reserved.
Video Part 1: Introduction & Spotlight on Nancy (Natl Dense Breast Disclosure Act)
Natl Dense Breast Disclosure Law (9/10/2024) Video Part 1
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WHAT ABOUT IF YOU'RE TOO YOUNG FOR A MAMMOGRAM? I went to my doctor for a lump I felt in my breast and she gave me a response that se...
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May 21, 2024, leading members of the NY Cancer Resource Alliance (NYCRA) held a special meeting with State Senator Patricia Canzoneri‐Fitzpa...
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The Women's Health Collaborative and EARLIER DETECTION advocate Alexandra Fiederlein interviewed breast cancer survivor Jamie Butera a...